Chelsea midfielder Frank Lampard (thigh) may return and centre-back Ricardo Carvalho is back after a ban.
Andriy Shevchenko (back) and John Terry (foot) are again out, while Mikel John Obi should be available after Africa Cup of Nations duty.
Liverpool will be without striker Fernando Torres (hamstring) along Andriy Voronin, Fabio Aurelio, Alvaro Arbeloa and Daniel Agger.
Xabi Alonso is suspended and Ryan Babel is a doubt with an ankle injury.
Chelsea (from): Cech, Cudicini, Hilario, Ferreira, Belletti, Carvalho, Ben-Haim, Alex, A Cole, Bridge, Ivanovic, Lampard, Makelele, Obi, J Cole, Wright-Phillips, Anelka, Pizarro, Malouda, Ballack, Sidwell.
Liverpool (from): Reina, Finnan, Carragher, Hyypia, Skrtel, Riise, Pennant, Mascherano, Gerrard, Babel, Benayoun, Kewell, Lucas, Crouch, Kuyt, Itandje.
Chelsea boss Avram Grant on the Blues' long unbeaten home record:
"Any record is good. Most of the time it is very positive but sometimes it affects you because you are afraid to lose. "I think it will be a difficult game. When the two clubs play against each other you always think about something from the past.
"Of course I don't have a problem with Liverpool, my only concern is that Chelsea will succeed."
Liverpool manager Rafael Benitez:
"Dirk Kuyt will probably be involved. It will not be rotation now, but something I will have to do. "I have no problems with Kuyt. He is a fantastic professional, a worker, so he does an important job for the team.
"There maybe is a problem with confidence, but if we create better chances he will score."